Proceeding2562

1605 การประชุมวิชาการระดับชาติมหาวิทยาลัยทักษิณ ครั้งที่ 29 ประจ�ำปี 2562 วิจัยและนวัตกรรมเพื่อการพัฒนาที่ยั่งยืน Prevalence of Thalassemia and Hemoglobinopathies in Chonburi Province Sanita Singsanan 1* , Kanokporn Srisucharitpanit 1 , Kultida Klarod 2 and Suticha Chunta 3 Abstract Introduction : Thalassemia is an autosomal recessive inherited blood disorder resulting from the decrease or absence of globin chain synthesis. This is the leading genetic problem in Thai population. Since the prevalence of thalassemia varies from different regions, the proportion of thalassemia risk varies, which affects control and prevention. Objective : This preliminary study aims to determine the prevalence of thalassemia and hemoglobinopathy in Chonburi people. Methods : Study in 140 Burapha University student volunteers who are domiciles in Chonburi province. Initial screening for thalassemia and hemoglobinopathy were performed using OF and DCIP test. Types of hb was determined by cellulose acetate electrophoresis or automated Hb analyzer. Detection of α -thalassemia, β -thal- assemia and hemoglobinopathy were determined by polymerase chain reaction. Results : The carrier rate for β -thalassemia1 (SEA deletion) trait were revealed 5 (3.57%), 21 (15%) α -Thalas- semia 2 trait including 19 (13.57%) of 3.7 kb deletion type and 2 (1.43%) of 4.2 kb deletion type. For β -thal- assemia, 4 (2.86%) β -thalassemia trait including β codon41/42 , β codon17 , β IVS2#654 and β -28 were detected. In addition, hemoglobinopathies analysis showed 24(17.14%) Hb E, 1(0.71%) Homozygous Hb E, 6 (4.29%) Hb Constant Spring, and 1 (0.50%) Hb Q-Thailand. As much as 11 genotypes were found. The hematological features were also comparatively presented. Conclusion: This study indicated the high prevalent of thalassemia and hemoglobinopathies. Therefore these data will be worthwhile for the control and prevention program of Thalassemia. Key words : α -thalassemia1, β -Thalassemia, Hemoglobinopathy