เอกสารการประชุมวิชาการและเสนอผลงานวิจัย มหาวิทยาลัยทักษิณ ครั้งที่ 19 2552 - page 945

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°· ¦³ (TAC) Ťn˜„˜nµŠ„´œ°¥nµŠ¤¸ œ´¥Îµ‡´šµŠ™·˜·š¸É¦³—´ .05
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Ťn˜„˜n µŠ‹µ„„¨»n¤‡ª‡»¤°¥nµŠ¤¸ œ´ ¥Îµ‡´šµŠ™· ˜·š¸É ¦³—´ .05 ˜n¤¸ÂœªÃœo¤Á¡·É¤ ¹Êœ¤µ„„ªnµ„¨»n¤‡ª‡»¤ nªœ
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š—¨°Šš¸É 1 ¡ªnµ‡nµÁŒ¨¸É ¥¦³—´µ¦˜o µœ°œ»¤¼¨°· ¦³ (TAC) Ťn˜„˜nµŠ„´ œ°¥nµŠ¤¸œ´ ¥Îµ‡´šµŠ™· ˜·š¸É ¦³—´ .05
˜n¤¸ÂœªÃœo¤Á¡·É¤ ¹Êœ¤µ„„ªnµ„¨»n¤š—¨°Šš¸É 1
Ž¹ÉŠ¦³—´µ¦˜oµœ°œ»¤¼¨°· ¦³ (TAC) š¸ÉÁ¡·É¤¼Š ¹Êœ ÁœºÉ°Š‹µ„„µ¦°°„„ε¨´Š„µ¥ÂÂ°Ã¦·„ Áž}œ„µ¦°°„
„ε¨´Š„µ¥š¸É˜n°ÁœºÉ°Š ¤¸ Ÿ¨˜n°„µ¦Äo°°„Ž·Á‹œÄœÁŽ¨¨r°Š¦nµŠ„µ¥Á¡·É¤¼Š ¹Êœ˜´ÊŠÂ˜n 10-200 ÁšnµÁ¤ºÉ°Áš¸¥„´ –³¡´„
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°°„Ž·Á‹œnªœ®œ¹ÉŠ‹³Á„· —Áž}œ°œ»¤¼¨°· ¦³ Ĝ¦³®ªnµŠ¤¸„µ¦™nµ¥š°—°·Á¨‡˜¦°œ‹µ„äÁ¨„»¨ °Š°°„Ž·Á‹œÅž¥´Š
äÁ¨„»¨ °ŠœÊÎ µÄœ„¦³ªœ„µ¦¨¼„ÃŽn œnŠ°·Á¨‡˜¦°œ (electron transport chain) —´Šœ´Êœ¥·ÉŠ¤¸ „µ¦Äo°°„Ž·Á‹œÄœ
ŤØ‡°œÁ—¦¸ ¥¤µ„ ¹ÊœÁšnµÄ— „È ‹³nŠŸ¨Ä®oÁ„·—°œ»¤¼¨°· ¦³¤µ„ ¹Êœ œ°„‹µ„œ´Êœ¡ªnµ catecholamine š¸É®¨´ÉŠ
°°„¤µÄœž¦·¤µ–¤µ„ –³¤¸„µ¦°°„„Î µ¨´Š„µ¥„È„n°Ä®oÁ„·—°œ»¤¼¨°· ¦³ÁnœÁ—¸¥ª„´œ Ž¹ÉŠÁ¤ºÉ°¦³—´µ¦˜oµœ°œ» ¤¼¨
°· ¦³Äœ¦nµŠ„µ¥Å¤n Á¡¸¥Š¡°Äœ„µ¦„ε‹´—°œ»¤¼¨°· ¦³ ‹¹ŠnŠŸ¨Ä®oÁ„·—£µª³ oxidative stress ¹Ê œ £µª³œ¸Ê¤¸Ÿ¨˜n°µ¦
¸ªÃ¤Á¨„»¨Îµ‡´Äœ¦nµŠ„µ¥ Án œ Þ¦˜¸œ ¨·žd— ¨³DNA šÎµÄ®oÁŽ¨¨rŗo¦´µ—Á‹È (Urso and Clarkson, 2003)
˜n„µ¦ f„°°„„ε¨´Š„µ¥ (training) Ĝ¦³¥³Áª¨µ®œ¹ÉŠ°¥nµŠ˜n°ÁœºÉ °Š °µ‹¤¸Ÿ¨˜n°„µ¦ž¦´˜´ª˜n °¦³ž„žj°ŠÁŽ¨¨r
‹µ„°œ» ¤¼¨°· ¦³ ×¥„µ¦Á¡·É¤¦³—´µ¦˜oµœ°œ»¤¼¨°· ¦³Á¡ºÉ°„ε‹´—°œ»¤¼¨°· ¦³Å¤nÄ®ošÎµ°´œ˜¦µ¥˜n°ÁŽ¨¨rĜ¦nµŠ„µ¥
(Moller et al., 1996) ×¥µ¦˜oµœ°œ»¤¼¨°· ¦³ ž¦³„°—o ª¥µ¦˜oµœ°œ»¤¼¨°· ¦³š¸É Áž}œ„¨»n¤Á°œÅŽ¤rĜ¦nµŠ„µ¥š¸É
¦oµŠ ¹Êœ (endogenous enzyme) ŗo„n catalase (CAT), superoxide dismutase (SOD) ¨³ glutathione peroxidase
(GPx) ¨³Ã¤Á¨„»¨š¸ÉŤnčnÁ°œÅŽ¤rŽ¹ÉŠÅ—o„n glutathione, albumin, bilirubin, ascorbic acid ¨³ alpha-tocopherol
Áž}œ˜oœ ץĜ„µ¦«¹„¬µœ¸Ê ŗošÎ µ„µ¦ª´—µ¦˜oµœ°œ»¤¼¨°· ¦³Ã—¥¦ª¤ (TAC) Ž¹ÉŠÁž}œ®œ¹É ŠÄœ˜´ª¸Êª´—¦³—´µ¦
˜oµœ°œ»¤¼¨š¸Éœ·¥¤ÄoĜ„µ¦ž¦³Á¤·œµ¦˜oµœ°œ» ¤¼¨°· ¦³š¸É µ¤µ¦™¨³¨µ¥œÊεŗo Ž¹ÉŠÄœ„µ¦«¹„¬µœ¸Êŗo šÎµ„µ¦
˜¦ª‹ª´ —¦³—´Äœ¡¨µ¤µ ‹µ„„µ¦«¹„¬µ °Š®š´¥„µ‹œr (2543) Ž¹ÉŠÅ—o«¹„¬µŸ¨ °Š„µ¦°°„„ε¨´Š„µ¥œ·—˜nµŠÇ
ŗo „n ¢»˜°¨ Á˜oœÂ°Ã¦·„ —¤·œ˜´œ ¨³ª·ÉŠ ץĮo„¨»n¤˜´ª°¥nµŠ°°„„ε¨´Š„µ¥´ž—µ®r¨³ 2 ‡¦´ÊŠ Áž}œÁª¨µ 8
´ž—µ®r ¡ªnµ¤¸Ÿ¨Á¡·É¤¦³—´µ¦˜oµœ°œ»¤¼¨°· ¦³ (TAC) Ĝ¡¨µ¤µÄœš»„œ·—„¸¯µ ĜšÎµœ°ŠÁ—¸ ¥ª„´œœ´„„¸¯µ
¢» ˜°¨š¸ÉÁ oµ¦nª¤Ãž¦Â„¦¤„µ¦ f„Žo°¤°¥nµŠ¤ÉÎ µÁ¤°Áž}œÁª¨µ 1 že ¤¸¦³—´µ¦˜oµœ°œ» ¤¼¨°· ¦³ (TAC) Ĝ
¡¨µ¤µÁ¡·É¤ ¹Êœ 25% Á¤ºÉ°Áž¦¸¥Áš¸¥„´„¨»n¤‡ª‡» ¤ (Brites et al., 1999)
œ°„‹µ„œ¸Ê Sukontachaya (2001) ŗošÎµ„µ¦«¹„¬µŸ¨ °Š„µ¦°°„„ε¨´Š„µ¥š¸É¤¸˜n°¦³—´ °Šµ¦˜o µœ
°œ»¤¼¨°· ¦³ÄœŸ¼o ¼Š°µ¥» ץĮo „¨»n¤š—¨°ŠšÎµ„µ¦°°„„ε¨´Š„µ¥—o ª¥„µ¦ž{~œ‹´ „¦¥µœš¸É¦³—´ ‡ªµ¤®œ´„ 70% °Š
°´˜¦µÎµ¦°Š„µ¦Á˜oœ®´ªÄ‹ Áž}œÁª¨µ 12 ´ ž—µ®r ¡ªn µ¦³—´ TAC ĜŽ¸¦´¤¤¸‡nµÁ¡·É¤¼Š ¹Êœ nªœŸ¨˜n°¦³—´µ¦