334
041
Öćøýċ
ÖþćđðøĊ
÷ïđìĊ
÷ïÖćøìćîĚĞ
ćöĆ
îóćøćôŗ
îǰÖĆ
ïǰÙøĊ
öđïÿǰêŠ
ĂÖćøÿĎ
âđÿĊ
÷îĚĞ
ćǰĔîñĎš
ðś
ü÷ēøÙÿąđÖĘ
éđÜĉ
î
Bilateral Comparison of Liquid Paraffin and Cream Base on Transepidermal
Water Loss Among Psoriasis Patients: a Randomized Trial
ßč
êĉ
öćǰßč
øĊ
1
*
ÿč
×č
öǰđÝĊ
÷öêî
2
ÖöúǰĂč
éú
3
ĒúąüúĆ
÷ĂøǰðøĆ
ßâóùìíĉĝ
4
Chutima Churee
1*
, Sukhum Jiamton
2
, Kamol Udol
3
and Walaiorn Pratchyapruit
4
ïìÙĆ
é÷Š
Ă
Öćøýċ
ÖþćîĊĚ
đóČę
ĂđðøĊ
÷ïđìĊ
÷ïÖćøÿĎ
âđÿĊ
÷îĚĞ
ćĒúąÙüćößčŠ
ößČĚ
îñĉ
üĀîĆ
ÜǰÝćÖÖćøìć liquid paraffinǰ(LP ǰÖĆ
ï
cream base (CB ǰĔîñĉ
üðÖêĉ
ĒúąøĂ÷ēøÙ×ĂÜñĎš
ðś
ü÷ēøÙÿąđÖĘ
éđÜĉ
îǰÝĞ
ćîüîǰ100 øć÷ ßîĉ
éñČę
îĀîćìĊę
öĊ
PASI Score îš
Ă÷ÖüŠ
ć 10ǰ
ēé÷đðøĊ
÷ïđìĊ
÷ï 2 ך
ćÜĔîÙîđéĊ
÷üÖĆ
î ǰìĞ
ćÖćøÿčŠ
öĔĀš
ך
ćÜĀîċę
Üìć LPǰïøĉ
đüèñĉ
üðÖêĉ
ĒúąøĂ÷ēøÙǰĒúąìćĂĊ
Öך
ćÜéš
ü÷ǰCBǰêøÜñĉ
üðÖêĉ
ĒúąøĂ÷ēøÙǰǰüĆ
îúąǰ2 ÙøĆĚ
Üǰ đßš
ć đ÷Ę
î ǰĒúš
üüĆ
éÙŠ
ćÖćøÿĎ
âđÿĊ
÷îĚĞ
ć ĒúąÙüćößčŠ
ößČĚ
îñĉ
üĀîĆ
ÜÖŠ
ĂîìćǰüĆ
éàĚĞ
ćĀúĆ
Üìćǰ60 îćìĊ
ǰĒúąìĊę
ǰ4ǰÿĆ
ðéćĀŤ
ǰ
ñúÖćøýċ
ÖþćóïüŠ
ćĔîïøĉ
đüèñĉ
üðÖêĉ
ǰÖćøìćéš
ü÷ǰCB öĊ
ÙŠ
ćÖćøÿĎ
âđÿĊ
÷îĚĞ
ćÝćÖñĉ
üĀîĆ
ÜǰöćÖÖüŠ
ćÖćøìćéš
ü÷ǰLP Ă÷Š
ćÜöĊ
îĆ
÷ÿĞ
ćÙĆ
âǰǰ
ìćÜÿëĉ
êĉ
ǰǰĒêŠ
ÙüćößčŠ
ößČĚ
îñĉ
üĀîĆ
ÜĕöŠ
öĊ
ÙüćöĒêÖêŠ
ćÜÖĆ
îǰÿŠ
üîĔîïøĉ
đüèøĂ÷ēøÙǰóïüŠ
ćÖćøìćéš
ü÷ǰLP ĒúąǰCB öĊ
ÙŠ
ćÖćøÿĎ
âđÿĊ
÷îĚĞ
ć
ÝćÖñĉ
üĀîĆ
ÜĕöŠ
ĒêÖêŠ
ćÜÖĆ
îǰĒêŠ
Öćøìćéš
ü÷ǰCB öĊ
ÙŠ
ćÙüćößčŠ
ößČĚ
îñĉ
üĀîĆ
ÜÿĎ
ÜÖüŠ
ćÖćøìćéš
ü÷ǰLPǰĂ÷Š
ćÜöĊ
îĆ
÷ÿĞ
ćÙĆ
âìćÜÿëĉ
êĉ
ÙĞ
ćÿĞ
ćÙĆ
â:
Öćøýċ
ÖþćĒïïÿčŠ
ö
ǰ
ēøÙÿąđÖĘ
éđÜĉ
î
ǰ
ÖćøÿĎ
âđÿĊ
÷îĚĞ
ćìćÜñĉ
üĀîĆ
ÜǰÙüćößčŠ
ößČĚ
îñĉ
üĀîĆ
Ü
ǰ
Abstract
The study aimed to evaluate skin moisturizing efficacy of liquid paraffin (LP ǰcompared with
cream base (CB ǰin normal skin and psoriasis lesions. One hundred participants with mild plaque type
psoriasis randomly selected apply twice daily in normal skin and psoriasis lesions, LP on one side and
CB on the other side. Transepidermal water lossǰ(TEWL ǰand skin hydration were measured at baseline,
60 minutes after application and the end of the 4
th
week. Results show that on normal skin, TEWL was
significantly greater in the area treated with CB than with LP, but there was no difference between the
two moisturizers regarding skin hydration. On psoriasis lesions, however, TEWL was not significantly
different in the area treated with LP compared to CB, but treatment with CB significantly improved skin
hydration compared to treatment with LP.
Keywords:
Randomized Control Trial,
Psoriasis,
Transepidermal Water Loss, Skin Hydration
1
îĉ
ÿĉ
êðøĉ
ââćēìǰÿć×ćüĉ
ì÷ćÖćøøąïćéǰÙèąĒóì÷ýćÿêøŤ
ýĉ
øĉ
øćßó÷ćïćúǰöĀćüĉ
ì÷ćúĆ
÷öĀĉ
éúǰÖøč
ÜđìóĄǰ10700
2
øý.éø.îó., õćÙüĉ
ßćêÝüĉ
ì÷ćǰÙèąĒóì÷ýćÿêøŤ
ýĉ
øĉ
øćßó÷ćïćúǰÖøč
ÜđìóĄǰ10700
3
ñý.îó., õćÙüĉ
ßćđüßýćÿêøŤ
ðŜ
ĂÜÖĆ
îĒúąÿĆ
ÜÙöǰÙèąĒóì÷ýćÿêøŤ
ýĉ
øĉ
øćßó÷ćïćúǰÖøč
ÜđìóĄǰ10700
4
Ă.óâ., ÿć×ćêÝüĉ
ì÷ć ÿëćïĆ
îēøÙñĉ
üĀîĆ
ÜǰÖøöÖćøĒóì÷Ť
ǰÖøąìøüÜÿćíćøèÿč
× Öøč
ÜđìóĄǰ10400
*
Corresponding author: Tel.: 086 1069446. E-mail address:
