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Abstract
Two unsymmetrical substituted thioureas, N-benzoyl- N',N'-diethylthiourea (1) and 1-benzoyl-3-[2-(3-
benzoyl-thioureido)-ethyl]-thiourea (2) have been synthesized from benzoyl chloride, ammonium thiocyanate and
corresponding amines under microwave irradiation, compared to the classical reflux method in acetone. It was
found that the synthesis of two substances under microwave irradiation using less amount of chemicals, water,
energy(electricity) and time, gave fair to good percent yield [ 1 (76.6%) and 2(64.8 %)] as same as the classical
reflux method [ 1 (74.2%) and 2(68.2 %)]. The complex preparation by the direct reaction of copper (I) iodide
with substituted thiourea , 1 and 2, gave green monoclinc crystals of copper complex Cu-1 (a = 10.5955(16), b =
18.3054(28), c = 13.4439(21) Å, E = 102.991(4)°) and mixture of yellow and pink crystals of copper complex
Cu-2. The X-ray analysis of copper complex Cu-1 crystal showed a square planar structure, with two molecules
of substituted thiourea ligands. Antifungal (Meliola sp., a plant pathogenic fungal) activity of 1, 2 and complex
Cu-1 have also been investigated by Agar dilution method. The thiourea 1 showed higher percent of inhibition on
Meliola sp. at 200-800 Pg/mL than complex Cu-1 but thiourea 2 showed no antifungal activity.
Keywords: Thiourea derivatives, Copper complex, Antifungal activity
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