เอกสารการประชุมวิชาการและเสนอผลงานวิจัย มหาวิทยาลัยทักษิณ ครั้งที่ 19 2552 - page 966

„µ¦ž¦³»¤ª·µ„µ¦Â¨³Áœ°Ÿ¨Šµœª·‹´¥¤®µª·š¥µ¨´¥š´ „¬·– ‡¦´Ê Šš¸É 19 ž¦³‹Îµže 2552
„µ¦—¼—Ž¹¤˜´ª¥µŸnµœŸ·ª®œ´ Šœ°„„µ¥ °Š‡µÁ¢°¸œ‹µ„°·¤´¨´œ
In Vitro Percutaneous Absorption of Caffeine from Emulsions
»œ· µ ¤¸Áœ1 ¨³¤§š´¥ ‹·˜˜£´„—¸ —·œš¦r2*
Sunisa Meesen1 and Somrutai Jitpukdeebodintra2*
š‡´—¥n°
‡µÁ¢°¸œÁž}œµ¦Á¡˜·—š¸É¤¸§š›·Í˜n°¦³Îµ‡´ °Š¦nµŠ„µ¥ ˜n™¼„œÎµ¤µÄoĜšµŠÁ‡¦ºÉ°ŠÎ µ°µŠ°¥nµŠ
„ªo µŠ ªµŠ®¨µ¥¦¼žÂ Ánœ ‡¦¸ ¤¨—¦·Êª¦°¥, ‡¦¸¤¨—¦°¥®¤°Š‡¨Êε¦°—ªŠ˜µ, Ÿ¨·˜£´ –”ržj°Š„´œŸ¤¦nªŠÂ¨³
Ÿ¨·˜£´ –”r„ε‹´—ÁŽ¨¨¼Å¨šr ª´˜™»ž¦³Š‡r°ŠŠµœª·‹´¥œ¸ÊÁ¡ºÉ°«¹„¬µ„µ¦Ž¹¤Ÿn µœŸ·ª®œ´Šœ°„„µ¥ °Š‡µÁ¢°¸œ‹µ„°· ¤´¨´ œ
Á¡ºÉ°œÎµŸ¨„µ¦«¹„¬µ¤µ¡´•œµŸ¨·˜£´–”rÄ®o‡µÁ¢°¸œÂš¦„Ž¹¤Á oµ¼nÁŒ¡µ³Ÿ·ª®œ´Š Ťn—¼—Ž¹¤Åž¥´Š°ª´¥ª³¦³°ºÉœÇ š¸É
‹³nŠŸ¨˜n°¦n µŠ„µ¥Å—o „µ¦«¹„¬µÅ—oš—¨°Š„µ¦Ž¹¤Ÿn µœŸ·ª®œ´Š °Š¨¼ „®¤¼š¸ÉÁ¸ ¥¸ª·˜®¨´Š‡¨°—š´œš¸ÂšœŸ·ª®œ´Š
¤œ» ¬¥r ‹µ„„µ¦š—¨°Š¡ªnµ‡µÁ¢°¸œÄœ°·¤´¨´œœ· —œÊε¤´œÄœœÊεŽ¹¤Ÿn µœŸ·ª®œ´Š¤µ„„ªnµœ·—œÊεĜ œÊε¤´œ—´Šœ´Êœ‹¹Šœ
¦»žªnµ„µ¦¡´•œµÂ¨³Á˜¦¸¥¤˜Î µ¦´Á‡¦ºÉ °ŠÎµ°µŠš¸É¤¸‡µÁ¢°¸œ‡ª¦Äo¦¼žÂ°·¤´¨´œœ·—œÊεĜœÊÎ µ¤´œ
‡ÎµÎµ‡´: ‡µÁ¢°¸œ, „µ¦—¼—Ž¹¤Ÿn µœŸ·ª®œ´Š, °·¤´¨´œ
ABSTRACT
Caffeine is narcotic drug affects to many important systems of the body, but it is widely applied in
many cosmetic forms, such as anti-wrinkles and anti-periobital hyperpigmentation products, hair lost
prevention, cellulite treatment products etc. The object of the research was to study i n vitro percutaneous
absorption of caffeine, now that the caffeine should not absorb to any other system of organ and took its action.
The experiment of percutaneous absorption through the newborn pig skin in stread of human skin was
comparatively studied between caffeine in oil in water emulsion and water in oil emulsion. The result showed that
caffeine amount was absorbed from oil in water emulsion was more than water in oil emulsion. So it was
concluded that water in oil emulsion should be considered for cosmetic formulation and preparation.
KEYWORDS: Caffeine, Percutaneous absorption, Emulsion
1œ´„«¹ „¬µž¦·µÃš ®¨´ „¼˜¦ª· š¥µ«µ˜¦¤®µ´–”· ˜ (ª· š¥µ«µ˜¦rÁ‡¦ºÉ °ŠÎµ°µŠ) ®¨´ „¼˜¦œµœµµ˜· ‡–³Á£´«µ˜¦r
¤®µª· š¥µ¨´¥Š ¨µœ‡¦· œš¦r ®µ—Ä®n ‹´Š®ª´—Š ¨µ 90112
2 Ÿ¼onª¥«µ˜¦µ‹µ¦¥r £µ‡ª·µÁš‡ÃœÃ¨¥¸Á£´ „¦¦¤ ‡–³Á£´«µ˜¦r ¤®µª· š¥µ¨´¥Š ¨µœ‡¦· œš¦r ®µ—Ä®n ‹´Š®ª´—Š ¨µ 90112
*Corresponding author: Ú¦«´¡šr 074-288841, Ú¦µ¦ 074-428148, E-mail:somrutai.j@psu.ac.th