เอกสารการประชุมวิชาการและเสนอผลงานวิจัย มหาวิทยาลัยทักษิณ ครั้งที่ 19 2552 - page 969

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that caffeine diffuses from o/w emulsion through the skin more than w/o emulsion in the same condition, so
caffeine from o/w emulsion was more absorbed into the bloodstream than w/o emulsion.
Fig. 1. Comparative caffeine diffused from water in oil (W/O) emulsion and oil in water (O/W) emulsion through
full thickness skin after 24 hrs application. (Caffeine assessed from receptor compartment of franz cell)
However caffeine in the skin was also assesses to assure the percutaneous absorption of caffeine into
the body. The result was shown in Fig.2. It showed that caffeine from o/w emulsion was accumulated in skin less
than caffeine from w/o emulsion. In conclusion caffeine from o/w emulsion was more penetrate through the skin
into the bloodstream than w/o emulsion.
Fig. 2. Comparative caffeine from water in oil (W/O) emulsion and oil in water (O/W) emulsion accumulated in
full thickness skin after 24 hrs application. (Caffeine assessed from receptors cell of franz cell)
Moreover caffeine did still not penetrate through skin was measured as shown in table 2, which
showed that caffeine in both types of emulsion did still remain on the top of the skin, where they were applied.