full2010.pdf - page 83

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Chemopreventive Effects of Grape Pomace Extract in Human Breast
Cancer Cell Line by Inducing The Apoptotic Pathway
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Nutthaya Chusing*
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Abstract
Effects of grape pomace extract from Shiraz grape on the phenolic compounds availability and apoptotic
actitivities was investigated. The ethanolic pomace extract (70% ethanol extraction) contained total phenolic
compounds of 1,743.504 ± 0.003 ôg of GAE/g. The relationship between concentration of pomace extract and
cytotoxic effects on MCF-7 cells was investigated by MTT assay. Significantly, pomace extract suppressed cancer
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°µ‹µ¦¥r —¦. µ µª·µ¸ªª·š¥µ ‡–³ª·š¥µ«µ˜¦r ¤®µª·š¥µ¨´¥š´„¬·– ¡´š¨»Š 93110
Dr., Department of Biology, Faculty of Science, Thaksin University, Phatthalung, 93110
* Corresponding author: Ú¦«´¡šr/Ú¦µ¦ 0 7460 9600 ˜n° 2251 E-mail:nutthaya@tsu.ac.th,nutthayavb77@hotmail.com