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£µ¡š¸É 2 Áž¦¸¥Áš¸¥¨Îµ—´„¦—°³¤·Ãœ °ŠÃž¦˜¸œ CCH ¦³®ªnµŠ Hevea (ADD69807), Ricinus (XP002533872),
Jatropha (ACV50430), Citrus (ABL67657), Solanum (ACB32235), Glycine (AAF15286), Lycopersicon
(AAP06757), Plantago (CAH59420), Zea mays (ACG30983), Arabidopsis (NP191183), Populus (AAT12488),
Homo (AAC51227) ¨³ Saccharomyces (AAC37428)
ǦŠ¦oµŠ˜˜·¥£¼¤·°ŠÃž¦˜¸œ HbCCH
‹µ„„µ¦šÎ µœµ¥Ã‡¦Š¦oµŠ˜˜·¥£¼¤·°ŠÃž¦˜¸œ HbCCH —oª¥ª·›¸ homology based modeling —oª¥Ãž¦Â„¦¤
SWISS-MODEL (Arnold et al., 2006) ץčoǦŠ¦oµŠŸ¨¹„ °Š Human copper transport protein ATOX1 (PDB
code 1fe0B) (Wernimont et al., 2000) š¸Éŗo ‹µ„„µ¦ª·Á‡¦µ³®r×¥ª·›¸ X-ray diffraction Áž} œÂ¤nÃ—¥¨Îµ—´„¦—
°³¤· ܦ³®ªnµŠ HbCCH „´ Human copper transport protein ATOX1 ¤¸‡nµ identity Ášnµ„´ 39.7 % ‡nµ RMSD š¸Éŗo
‹µ„„µ¦ superposition ¦³®ªnµŠÃ‡¦Š¦oµŠ®¨´ „¨³Â˜n¨³°³˜°¤£µ¥ÄœÃ‡¦Š¦oµŠ˜˜·¥£¼¤·°Šš´ÊŠ°ŠÃ‡¦Š¦o µŠ
¡ªnµ¤¸‡nµÁšnµ„´œ‡º° 1.75 Š—Šªn µÃ‡¦Š¦oµŠ˜˜·¥£¼¤·°Š HbCCH ‡¨oµ¥„´ Ã‡¦Š¦oµŠ˜˜·¥£¼¤·°Š Human copper
transport protein ATOX1 Ž¹É Š¡ªn µÃ‡¦Š¦oµŠ˜˜·¥£¼¤·°Š HbCCH ž¦³„°—o ª¥ 4 E-sheets ¨³ 2 D-helixs
Á¦¸¥Š¨Îµ—´—´Šœ¸Ê E-sheet-D-helix- E-sheet- E-sheet-D -helix- E-sheet Ž¹ÉŠ metal binding domain (MXCXXC) °¥¼n¦· Áª–