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µ¤µ¦™Á‹¦·š´ÊŠ 2 £µª³ „ÈÁ¡ºÉ°‡ªµ¤‹ÎµÁž}œÄœ„µ¦œÎ µÅžÄoĜ¦³šµŠÁ—· œ°µ®µ¦Á¡¦µ³Äœ¦³šµŠÁ—·œ°µ®µ¦
nªœÄ®n‹³¡ÁºÊ°¡ª„ anaerobe ¤¸‹Îµœªœ¤µ„„ªnµ aerobe Ĝ°´ ˜¦µnªœ 1000 : 1 (œª¨‹·¦µ £´š¦¦´Š¦°Š, 2538)
5. ÂŸœ‡ªµ¤Åª °ŠÁºÊ°˜n°¥µž’·¸ªœ³
œÎ µÂ‡š¸Á¦¸¥Â¨„˜·„‹Î µœªœ 10 ŰÎÁ¨˜¤µš—°ž¦³·š›·£µ¡„µ¦¥´¥´ÊŠ„µ¦Á‹¦·Ã—¥¥µž’·¸ªœ³
15 œ·—×¥ª·›¸ disc diffusion —ŠÄœ˜µ¦µŠš¸É 2 ¡ªnµ ŰÎÁ¨˜ CC1 CC2 CC3 CC4 CC5 CC6 CC7 CC8 CC9
¨³ CC11 —ºÊ°˜n°¥µž’·¸ªœ³š¸É¤¸„¨Å„ ´— ªµŠ„µ¦šÎ µŠµœ °ŠÁ¥ºÉ°®»o¤ÁŽ¨¨r Ánœ polymyxin B „¨Å„¥´¥´ÊŠ„µ¦
´ŠÁ‡¦µ³®rŸœ´ŠÁŽ¨¨r Ánœ bacitracin „¨Å„¥´¥´ÊŠ„µ¦´ŠÁ‡¦µ³®rÞ¦˜¸œ Ánœ streptomycin ¨³ kanamycin ¨³ÁºÊ°Åª
˜n°¥µž’· ¸ªœ³ ampicillin, chloramphenicol, tetracycline ×¥°—‡¨o°Š„´ ¦µ¥Šµœ °Š¥«ª¸ (2549) Ž¹ÉŠ‡´—Â¥„
‡š¸ Á¦¸¥„¦—¨„˜·„‹µ„°µ®µ¦®¤´„ ×¥nªœÄ®n —ºÊ°˜n°¥µž’·¸ªœ³¡ºÊœ“µœŽ¹É ŠÁž}œ¥µ„¨»n¤˜nµŠÇš¸Éčo¦´„¬µšµŠ
‡¨· œ·„ Ánœ Penicillin G, Ampicillin, Vancomycin, Cloramphenical ®¦º° Ciprofloxacin (Halami et al.,2000 and
Coppola et al., 2005) ¨³Åª˜n°¥µž’· ¸ªœ³ ampicillin, tetracycline, vancomycin, gentamycin, chloramphenical
¨³ erythromycin (Temmerman et al., 2002; Danielsen and Wind., 2003; Mathur and Singh.,2005)
‡š¸Á¦¸¥„¦—¨„˜·„Å°ÃŽÁ¨˜ CC2 CC3 CC4 ¨³ CC6 —ºÊ °˜n°¥µž’·¸ªœ³ Ceflazidime ˜n ‡š¸Á¦¸ ¥
á¦ÅÃ°˜·„r µ¥¡´œ›»r¤µ˜¦“µœ L. casei TISTR 390 Ū˜n°¥µž’·¸ªœ³—´Š„¨nµª ŰÎÁ¨˜ CC9 CC11 —ºÊ °˜n°¥µ
vancomycin Ž¹ÉŠÅ¤n °—‡¨o°Š„´Ÿ¨„µ¦ª·‹´¥š¸É Á‡¥¦µ¥ŠµœŸnµœ¤µ°¸ „®¨µ¥Œ´š¸É¸ÊÄ®o Á®Èœªnµ ‡š¸Á¦¸ ¥Â„¦¤ª„
¦ª¤™¹ŠÂ‡š¸Á¦¸ ¥„¦—¨„˜·„‹³™¼„šÎµ¨µ¥Å—oŠnµ¥Ã—¥¥µ vancomycin Ž¹ÉŠÁž}œ¥µž’·¸ªœ³„¨»n¤ Glycopeptide š¸É µ¤µ¦™
¥´¥´Ê Š„µ¦´ŠÁ‡¦µ³®r Peptidoglycan Ž¹É ŠÁž}œ°Š‡rž¦³„° °ŠŸœ´ŠÁŽ¨¨r‡š¸Á¦¸¥ (Reynolds, 1989) —´ Šœ´ÊœÁºÊ°š¸É—ºÊ°
˜n°¥µž’· ¸ªœ³„¨»n ¤˜nµŠÇ ŗo®¨µ¥„¨»n¤‹¹Š¤¸o°—¸ ‡º°‡ªµ¤šœšµœ °ŠÁºÊ°˜n°„µ¦œÎµÅžÄo¦nª¤„´¥µ
6. „µ¦š—°‡ªµ¤µ¤µ¦™ °ŠÁºÊ°Â‡š¸Á¦¸¥„¦—¨„˜·„Äœ„µ¦¥´¥´ÊŠÁºÊ°Â‡š¸Á¦¸¥n Š¸ÊĜ£µª³š¸ÉŤn
‹Î µ„´—„¦—°·œš¦¸¥r¨³Å±Ã—¦Á‹œÁž°¦r°°„ÅŽ—r ×¥ª·›¸ agar well diffusion
œÎµÂ‡š¸ Á¦¸¥„¦—¨„˜·„‹Î µœªœ 10 ŰÎÁ¨˜ ¤µš—°‡ªµ¤µ¤µ¦™Äœ„µ¦¥´¥´ÊŠÂ‡š¸Á¦¸¥ °·œ—·Á‡Á˜°¦r
2 µ¥¡´ œ›»r ŗo „n Staphylococcus aureus TISTR 517 ¨³ Escherichia coli TISTR 887 ¡ªnµš» „Å°ÃŽÁ¨˜µ¤µ¦™
¥´¥´ÊŠ S. aureus TISTR 517 ŗo×¥¤¸ªŠÄ„µ¦¥´¥´ÊŠ¤µ„„ªn µ 10 ¤·¨¨·Á¤˜¦Â¨³Å°ÃŽÁ¨˜ CC5 CC6 CC7 CC8 CC9
CC11 µ¤µ¦™¥´ ¥´ÊŠ E. coli TISTR 887 ŗo×¥¤¸ªŠÄ„µ¦¥´¥´ÊŠ¤µ„„ªn µ 10 ¤·¨¨·Á¤˜¦ ŰÎÁ¨˜ CC9 µ¤µ¦™
¥´¥´ÊŠÂ‡š¸Á¦¸¥ S. aureus TISTR 517 ŗo —¸š¸É »—×¥¤¸ªŠÄ„µ¦¥´¥´ÊŠÁšnµ„´ 18 ¤·¨¨·Á¤˜¦(£µ¡š¸É 2) ŰÎÁ¨˜ CC11
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®¤´„ °ŠÅš¥‡º° Lactobacillus brevis, Lactobacillus bavaricus 3 µ¥¡´œ›»r¨³ Lactobacillus plantarum 16 µ¥
¡´œ›»r ¤µ¥´¥´ÊŠ E. coli, Bacillus cereus , Vibrio parahaemolyticus, Salmonella typhimurium ¨³ S. aureus ×¥¡ªnµ
¤¸ nªœÄ„µ¦¥´¥´Ê Š t10 ¤¤. ˜n°Â‡š¸Á¦¸ ¥š¸Éš—°°¥nµŠœo°¥ 3 œ·—