535
Parameters
Baseline TC
5.18 mmol/l
Baseline TC 5.18 mmol/l
Control (n=9)
SPI (n=8)
Control (n=9)
SPI (n=10)
Total cholesterol
Baseline
5.72±0.39
5.77±0.36
4.61±0.36
4.76±0.15
(mmol/l)
Week 6
5.11±1.06
4.88±0.73
À
5.01±1.09
4.56±1.00
LDL cholesterol
Baseline
3.63±0.55
3.71±1.10
2.49±0.59
2.81±0.27
(mmol/l)
Week 6
3.09±1.07
2.88±0.54
2.89±0.74
2.16±1.10
HDL cholesterol
Baseline
1.47±0.32
1.51±0.32
1.27±0.18
1.37±0.43
(mmol/l)
Week 6
1.38±0.30
1.38±0.12
1.14±0.42
1.23±0.33
TG
Baseline
1.51±0.57
1.78±0.40
1.61±0.53
1.32±0.42
(mmol/l)
Week 6
1.55±0.57
1.55±0.41
1.79±0.50
1.22±0.57
n = number, SPI = soy protein isolate, LDL = low density lipoprotein cholesterol, HDL = high density lipoprotein, TG = triglyceride,mmol/l = millimole per liter
1
data expressed as mean ± SD
À
significant difference
from baseline (
p
=0.04)
TABLE 4 Correlation between baseline hs-CRP with HbA1c
1
hs-CRP
r
value
P
value
hs-CRP
(mg/l)
1
-
HbA1c
(mg%)
0.330
0.049*
hs-CRP= high sensitivity C-reactive protein, mg/l = milligram per litre, mg% = milligram percentage
1
statistic analysis by Pearson correlation coefficients in all subjects (n=36) at baseline
À
significant correlation
p
<0.05
Discussion
In the present study, after 6 weeks of SPI supplementation in type 2 diabetic patients, HbA1c values
were decreased from baseline. Indeed, a dose of 30-g SPI containing 32 mg of isoflavones per day was well
tolerated and did not cause significant side effects.
SPI supplementation causes positive effects on glycemic control demonstrated by significant reductions
in HbA1c and trend toward reduction in blood lipids compared with baseline in type 2 diabetic subjects
.
The
findings agree with
studies in type 2 diabetic subjects supplemented isoflavones in combination with soy protein
for 12 weeks, mean values for HbA1c, fasting insulin, TC and LDL-C significantly reduce when compared with
placebo (Jayagopal et al., 2002). Soy protein enriched isoflavones supplementation reduced serum LDL-C with a
greater degree than group of isoflavones-depleted soy protein at the same amount of soy protein (Taku et al.,
2007). However, daily supplementation with purified isoflavones found no effect on plasma glucose, HbA1c,
insulin resistance and lipid profile (Gonzalez et al., 2007). There is the possibility that soy isoflavones had
