534
The effect of 6-week SPI supplementation on glycemic control (expressed by HbA1c levels) and lipid
profiles are reported in Table 2. HbA1c of the SPI group was significantly decreased from baseline (
p
=0.003). SPI
supplement resulted in reduction in serum TC, LDL-C, TG, but the results did not significantly differ from the
baseline. However, TC was significantly decreased from baseline in the subjects of the SPI group with baseline
TC higher than 5.18 mmol/l (200 mg/dl) (
p
=0.04) (Table 3).The hs-CRP concentrations of the subjects in SPI
group were nearly significantly decreased from baseline (Table 2). At baseline, hs-CRP concentrations were
significantly positively correlated with HbA1c (
r
=0.33,
p
=0.049) (Table 4).
TABLE 2 Effects of SPI supplementation on Biomarkers of CVD
1
Parameters
Control (n=18)
SPI (n=18)
Difference groups
(
p
-value)
2
FPG
(mmol/l)
Baseline
6.39±0.96
6.63±0.98
0.153
Week 6
6.99±1.03
6.49±1.01
Mean change
0.60±1.89
-0.14±1.01
HbA1c
(mg%)
Baseline
7.07±0.90
6.99±1.12
0.374
Week 6
6.97±1.17
6.65±0.93
Mean change
-0.27±0.57
-0.34±0.42**
Total cholesterol
(mmol/l)
Baseline
5.16±0.68
5.13±0.76
0.281
Week 6
5.06±1.05
4.70±0.88
Mean change
-0.11±1.28
-0.43±0.97
LDL cholesterol
(mmol/l)
Baseline
3.06±0.80
3.12±0.98
0.489
Week 6
2.99±0.90
2.79±0.78
Mean change
-0.07±1.25
-0.33±1.15
HDL cholesterol
(mmol/l)
Baseline
1.37±0.27
1.43±0.38
0.637
Week 6
1.27±0.34
1.33±0.31
Mean change
-0.09±0.24
-0.11±0.25
TG
(mmol/l)
Baseline
1.56±0.54
1.53±0.46
0.102
Week 6
1.67±0.53
1.38±0.52
Mean change
0.11±0.42
-0.15±0.52
hs-CRP
(mg/l)
Baseline
1.44±0.65
1.59±1.11
0.322
Week 6
1.42±0.77
1.10±0.32
Mean change
-0.02±1.10
-0.41±1.07
Table 3 Effects of SPI supplementation on lipid profile of subjects with baseline TC
5.18 mmol/l or < 5.18 mmol/l
1
n = number, SPI = soy protein isolate, FPG = fasting plasma glucose, mmol/l = millimole per liter, mg% = milligram percentage, LDL = low density lipoprotein,
HDL = high density lipoprotein, TG = triglyceride, hs-CRP= high sensitivity C-reactive protein, mg/l = milligram per litre
1
data expressed as mean ± SD
2
statistic analysis by Independent
t
-test at week 6
À
significant difference from baseline (
p
<0.05)
ÀÀ
significant difference from baseline (
p
<0.01)
