1331
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Effects of Human Beta-Defensin-1, -2 and -3 on Osteoclastogenesis
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Thanapat Sripontong
1
*
, PattaninǰMontreekachon
2
, Sakornrat Khongkhunthian
3
, Chayarop Supanchart
4
,
and Suttichai Krisanaprakornkit
5
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Abstract
This study was
JOǰWJUSP
study about effects of hBD-1, -2 and -3 on osteoclastogenesis Whole-blood
samples were obtained from healthy volunteer; human osteoclast progenitor cells were isolated from
human peripheral blood mononuclear cells To determine the cytotoxicity of hBDs, cultured osteoclasts
were treated with different concentrations of hBD-1, -2 or -3 by MTT assay The cells were cultured in the
presence of non-toxic doses of hBDs during an
JOǰWJUSP
induction of osteoclastogenesis The results shown
that hBD-1 could enhance multinuclear formation and formation of resorption pits On the other hand,
hBD-3 could inhibit osteoclast formation and diminish the formation of resorption pits Whereas, hBD-2 has
no effect on osteoclastogenesis In conclusion, the results of the present study showed a differential effect
of hBD-1, -2 and -3 on osteoclastogenesis.
Keywords
Human Beta-Defensin-1, -2 and -3, Osteoclast, Osteoclastogenesis
1
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Öýċ
Öþćðøĉ
ââćēì ÿć×ćðøĉ
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öĀćüĉ
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÷đßĊ
÷ÜĔĀöŠ
50200
2
Ă.ìóâ.éø. õćÙüĉ
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÷đßĊ
÷ÜĔĀöŠ
50200
3
ñý.ìóâ.éø. õćÙüĉ
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÷đßĊ
÷ÜĔĀöŠ
50200
4
Ă.ìó.éø. õćÙüĉ
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ĂÜðćÖĒúąĒöĘ
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÷ÜĔĀöŠ
50200
5
ý.ìó.éø. õćÙüĉ
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÷đßĊ
÷ÜĔĀöŠ
50200
*
Corresponding author Tel. 087-2144854. E-mail address
